Article
Exclusion of the DYT1 locus in a non-Jewish family with early-onset dystonia.
Movement disorders : official journal of the Movement Disorder Society - 1 Nov 1994
Bressman S B, Hunt A L, Heiman G A, Brin M F, Burke R E, Fahn S, Trugman J M, de Leon D, Kramer P L, Wilhelmsen K C
Abstract excerpt
The DYT1 gene on chromosome 9q34 underlies idiopathic torsion dystonia (ITD) in Jewish and non-Jewish families with childhood and adolescent-onset dystonia that usually starts in a limb, spreads to other limbs, and uncommonly involves cranial muscles. We examined 39 members of a Mennonite family of German ancestry in which seven were affected with ITD. Age at onset was 14.7 years (range 5-34 years) and symptoms...
Topics
- Adolescent
- Adult
- Age Factors
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- Dystonia Musculorum Deformans
- Ethnicity
- Female
- Genetic Linkage