Article
Strong allelic association between the torsion dystonia gene (DYT1) andloci on chromosome 9q34 in Ashkenazi Jews.
American journal of human genetics - 1 Mar 1992
Ozelius L J, Kramer P L, de Leon D, Risch N, Bressman S B, Schuback D E, Brin M F, Kwiatkowski D J, Burke R E, Gusella J F
Abstract excerpt
The DYT1 gene responsible for early-onset, idiopathic torsion dystonia (ITD) in the Ashkenazi Jewish population, as well as in one large non-Jewish family, has been mapped to chromosome 9q32-34. Using (GT)n and RFLP markers in this region, we have identified obligate recombination events in some of these Jewish families, which further delineate the area containing the DYT1 gene to a 6-cM region bounded by loci...
Topics
- Alleles
- Chi-Square Distribution
- Chromosome Mapping
- Chromosomes, Human, Pair 8
- Crossing Over, Genetic
- DNA Probes
- Dystonia Musculorum Deformans
- Europe, Eastern
- Gene Expression
- Genes, Dominant