Article
Secondary dystonia and the DYTI gene.
Neurology - 1 Jun 1997
Bressman S B, de Leon D, Raymond D, Greene P E, Brin M F, Fahn S, Ozelius L J, Breakefield X O, Kramer P L, Risch N J
Abstract excerpt
Early-onset (< 28 years) primary dystonia in most Ashkenazi Jews is due to a single founder mutation in the DYT1 gene on chromosome 9q34, as determined by very strong linkage disequilibrium with a haplotype of 9q34 alleles at surrounding marker loci. The role of this mutation in individuals with secondary causes for dystonia has never been tested, although environmental insults, such as neuroleptic exposure or...
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