Article
Secondary dystonia and the DYTI gene.
Neurology - 1 Jun 1997
Bressman S B, de Leon D, Raymond D, Greene P E, Brin M F, Fahn S, Ozelius L J, Breakefield X O, Kramer P L, Risch N J
Abstract excerpt
Early-onset (< 28 years) primary dystonia in most Ashkenazi Jews is due to a single founder mutation in the DYT1 gene on chromosome 9q34, as determined by very strong linkage disequilibrium with a haplotype of 9q34 alleles at surrounding marker loci. The role of this mutation in individuals with...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Alleles
- Child
- Chromosomes, Human, Pair 9
- Dystonia
- Female
- Genetic Linkage
- Genetic Markers
- Haplotypes
- Humans
- Jews
- Male
- Middle Aged
- Mutation
- Phenotype