Phylogenetic analysis of Leber's hereditary optic neuropathy mitochondrial DNA's indicates multiple independent occurrences of the common mutations.

doi:10.1002/humu.1380060405

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Article

Phylogenetic analysis of Leber's hereditary optic neuropathy mitochondrial DNA's indicates multiple independent occurrences of the common mutations.

Human mutation - 1 Jan 1995

Brown M D, Torroni A, Reckord C L, Wallace D C

Abstract excerpt

The mitochondrial DNAs (mtDNA) from 17 Caucasian 11778-positive and 30 Caucasian 11778-negative Leber's hereditary optic neuropathy (LHON) patients were PCR-amplified and subjected to high resolution restriction endonuclease analysis. Concurrently, all patient mtDNAs were screened for the common...

Topics

DNA, Mitochondrial
Genetic Testing
Haplotypes
Humans
Mutation
Optic Atrophies, Hereditary
Phylogeny
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
White People

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