Article
Secretory component mRNA and protein expression in colorectal adenomas and carcinomas.
British journal of cancer - 1 Jun 1996
Krajci P, Meling G I, Andersen S N, Hofstad B, Vatn M H, Rognum T O, Brandtzaeg P
Abstract excerpt
Secretary component (SC) is expressed basolaterally as a transmembrane protein (pIg receptor) on secretory epithelial cells. As pIg receptor it plays a central role in humoral immunity by mediating the external translocation of dimeric IgA and pentameric IgM. A few case reports have suggested that reduced or absent SC protein expression is associated with diarrhoeal disease, but there is no convincing evidence...
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