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Article

Depression spectrum disease, I: The role of gene-environment interaction.

The American journal of psychiatry - 1 Jul 1996

Cadoret R J, Winokur G, Langbehn D, Troughton E, Yates W R, Stewart M A

Abstract excerpt

OBJECTIVE: This study used an adoption study design to separate genetic from environmental factors in the etiology of depression spectrum disease, a type of major depression characterized by families in which male relatives are alcoholic and females are depressed. The genetic etiology hypothesis of depression spectrum disease proposes that an alcoholic genetic diathesis predisposes to depression in females but...

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PMID: 8659611
DOI: 10.1176/ajp.153.7.892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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