Article
Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders.
Cell - 17 May 1996
Downing A K, Knott V, Werner J M, Cardy C M, Campbell I D, Handford P A
Abstract excerpt
The nuclear magnetic resonance structure of a covalently linked pair of calcium-binding (cb) epidermal growth factor-like (EGF) domains from human fibrillin-1, the protein defective in the Marfan syndrome, is described. The two domains are in a rigid, rod-like arrangement, stabilized by interdoma...
Topics
- Calcium-Binding Proteins
- Connective Tissue Diseases
- Epidermal Growth Factor
- Humans
- Image Processing, Computer-Assisted
- Marfan Syndrome
- Microfilament Proteins
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Protein Structure, Tertiary
- Sequence Homology, Amino Acid