Article
Sterol esterification in yeast: a two-gene process.
Science (New York, N.Y.) - 31 May 1996
Yang H, Bard M, Bruner D A, Gleeson A, Deckelbaum R J, Aljinovic G, Pohl T M, Rothstein R, Sturley S L
Abstract excerpt
Unesterified sterol modulates the function of eukaryotic membranes. In human cells, sterol is esterified to a storage form by acyl-coenzyme A (CoA): cholesterol acyl transferase (ACAT). Here, two genes are identified, ARE1 and ARE2, that encode ACAT-related enzymes in yeast. The yeast enzymes are 49 percent identical to each other and exhibit 23 percent identity to human ACAT. Deletion of ARE2 reduced sterol...
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