Article
Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.
Molecular and cellular biology - 1 Jun 1996
Molkentin J D, Black B L, Martin J F, Olson E N
Abstract excerpt
There are four members of the myocyte enhancer factor 2 (MEF2) family of transcription factors in vertebrates, MEF2A, -B, -C, and -D, which have homology within a MADS box at their amino termini and an adjacent motif known as the MEF2 domain. These factors activate muscle gene expression by binding as homo- and heterodimers to an A/T-rich DNA sequence in the control regions of muscle-specific genes. To understand...
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