Article
A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila.
Developmental biology - 1 Sept 1995
Ranganayakulu G, Zhao B, Dokidis A, Molkentin J D, Olson E N, Schulz R A
Abstract excerpt
The D-mef2 gene encodes a MADS domain transcription factor expressed in differentiated muscles and their precursors in the Drosophila embryo. Embryos deficient for D-MEF2 protein due to a deletion of upstream transcriptional control sequences fail to form muscle, suggesting that the gene is required for muscle cell differentiation. To directly demonstrate a role for D-mef2 in embryonic myogenesis, we isolated...
Topics
- Animals
- Apoptosis
- Base Sequence
- DNA Primers
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Female
- Gene Expression Regulation, Developmental
- Genes, Insect
- Integrins