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Quantification of X-chromosome inactivation patterns in haematological samples using the DNA PCR-based HUMARA assay.

Leukemia - 1 Feb 1996

Gale R E, Mein C A, Linch D C

Abstract excerpt

Quantification of X-chromosome inactivation patterns (XCIPs) using PCR amplification of the human androgen receptor (HUMARA) locus is potentially valuable in a range of haematological disorders. Of 236 females screened, 203 (86%) were heterozygous. For quantitative XCIPs it was necessary to limit the number of PCR cycles to 20 to reduce preferential amplification of shorter alleles. The optimized PCR method was...

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PMID: 8637249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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