Article
Characterization of the GDP-D-mannose biosynthesis pathway in Coxiella burnetii: the initial steps for GDP-β-D-virenose biosynthesis.
PloS one - 1 Jan 2011
Narasaki Craig T, Mertens Katja, Samuel James E
Abstract excerpt
Coxiella burnetii, the etiologic agent of human Q fever, is a gram-negative and naturally obligate intracellular bacterium. The O-specific polysaccharide chain (O-PS) of the lipopolysaccharide (LPS) of C. burnetii is considered a heteropolymer of the two unusual sugars β-D-virenose and dihydrohydroxystreptose and mannose. We hypothesize that GDP-D-mannose is a metabolic intermediate to GDP-β-D-virenose....
Topics
- Bacterial Proteins
- Biocatalysis
- Biosynthetic Pathways
- Coxiella burnetii
- Deoxy Sugars
- Escherichia coli
- Guanosine Diphosphate Mannose
- Guanosine Diphosphate Sugars
- Humans
- Kinetics
- Lipopolysaccharides
- Mannose-6-Phosphate Isomerase
- Mutation
- Nucleotidyltransferases