Article
Molecular mechanisms of thalassemia in southeast Asia.
The Southeast Asian journal of tropical medicine and public health - 1 Jan 1995
Winichagoon P, Fucharoen S, Wilairat P, Fukumaki Y
Abstract excerpt
Hemoglobinopathies are the most common genetic disorders in Southeast Asia. alpha-Thalassemia is most often due to a alpha-globin gene deletion. Hb Constant Spring (CS) occurs from the mutation at the termination codon of the alpha-globin gene resulting in an elongated polypeptide; alpha(CS)-globin mRNA is also unstable and only small amounts of Hb CS are produced. Thus Hb CS has an alpha-thalassemia 2-like...
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