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Article

In vivo model of adeno-associated virus vector persistence and rescue

1 May 1996

Abstract excerpt

Gene therapy vectors based on human DNA viruses could be mobilized or rescued from individuals who are subsequently infected with the corresponding wild-type (wt) helper viruses. This phenomenon has been effectively modeled in vitro with both adenovirus (Ad) and adeno-associated virus (AAV) vectors but has not previously been studied in vivo. In the current study, we have developed an in vivo model to study the...

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PMID: 8627804
DOI: 10.1128/jvi.70.5.3235-3241.1996

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