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Article

The mutagenic effect of elevated temperatures in yeast is blocked by a previous heat shock.

Mutation research - 1 Oct 1993

Nunes E, Candreva E C, Keszenman D, Salvo V A

Abstract excerpt

We have analyzed the mutagenic effect of elevated temperatures (hyperthermia: HT) either upon direct exposure or after a previous heat shock (HS) in the haploid auxotrophic Saccharomyces cerevisiae strain SC7K lys2-3 in the logarithmic phase of growth. We demonstrated a significant antimutagenic effect of HS (38 degrees C for 1 h) followed by hyperthermia (48 degrees C, up to 60 min). Using cycloheximide (CHM)...

Topics

Adaptation, Physiological
Antimutagenic Agents
Cycloheximide
DNA Repair
Enzyme Induction
Fungal Proteins
Gene Expression Regulation, Fungal
Heat-Shock Proteins
Hot Temperature
Mutagenesis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Denaturation

Saccharomyces cerevisiae

Source

Identifiers

PMID: 7690884
DOI: 10.1016/0027-5107(93)90066-o

Genes

CHM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7690884-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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