Article
Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease.
Clinical and experimental immunology - 1 May 1996
Botto M, Theodoridis E, Thompson E M, Beynon H L, Briggs D, Isenberg D A, Walport M J, Davies K A
Abstract excerpt
An allotypic variant of Fc gamma RIIa, Fc gamma RIIa-HR (Fc gamma RIIa-R131), has been shown in vitro to reduce the capacity of phagocytic cells to bind and internalize IgG-containing immune complexes. Our aim was to determine whether this allotypic variant was associated with susceptibility to SLE and the development of lupus nephritis, as previous studies have suggested. Fc gamma RIIA genotype analysis was...
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