Article
Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 1996
Mizuno T M, Bergen H, Funabashi T, Kleopoulos S P, Zhong Y G, Bauman W A, Mobbs C V
Abstract excerpt
Mutations in the obese (ob) gene lead to obesity. This gene has been recently cloned, but the factors regulating its expression have not been elucidated. To address the regulation of the ob gene with regard to body weight and nutritional factors, Northern blot analysis was used to assess ob mRNA in adipose tissue from mice [lean, obese due to diet, or genetically (yellow agouti) obese] under different nutritional...
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