Article
Preliminary evidence for genetic anticipation in Crohn's disease.
Lancet (London, England) - 23 Mar 1996
Polito J M, Rees R C, Childs B, Mendeloff A I, Harris M L, Bayless T M
Abstract excerpt
BACKGROUND: The term genetic anticipation is used to describe earlier onset of disease, increased severity, or both, in succeeding generations of families affected by a particular disease. This process has been linked with expanded genomic trinucleotide repeat regions in some neurological disorders. Crohn's disease, an inflammatory bowel disorder, has genetic influences, which remain undefined. We studied pairs...
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