Article
ROD1, a novel gene conferring multiple resistance phenotypes in Saccharomyces cerevisiae.
The Journal of biological chemistry - 9 Feb 1996
Wu A L, Hallstrom T C, Moye-Rowley W S
Abstract excerpt
Glutathione-dependent detoxification reactions are catalyzed by the enzyme glutathione S-transferase and are important in drug resistance in organisms ranging from bacteria to humans. The yeast Issatchenkia orientalis expresses a glutathione S-transferase (GST) protein that is induced when the GST substrate o-dinitrobenzene (o-DNB) is added to the culture. In this study, we show that overproduction of the I....
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