Article
p53 mutations and clonality in vulvar carcinomas and squamous hyperplasias: evidence suggesting that squamous hyperplasias do not serve as direct precursors of human papillomavirus-negative vulvar carcinomas.
Human pathology - 1 Apr 1996
Kim Y T, Thomas N F, Kessis T D, Wilkinson E J, Hedrick L, Cho K R
Abstract excerpt
Previous studies of vulvar carcinomas have shown two distinct subsets with respect to several clinicopathologic features. In younger women, the tumors are frequently human papillomavirus (HPV) positive, are usually of basaloid or warty histology, and are associated with vulvar intraepithelial neo...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
- Exons
- Female
- Genes, p53
- Humans
- Hyperplasia
- Middle Aged
- Mutation
- Papillomaviridae
- Papillomavirus Infections
- Precancerous Conditions
- Vulva