Article
Immunohistochemical localization of telomerase hTERT protein and analysis of clonality in multifocal vulvar intraepithelial neoplasia.
American journal of clinical pathology - 1 Sept 2000
Wada H, Enomoto T, Yoshino K, Ozaki K, Kurachi H, Nomura T, Murata Y, Kim N, Weinrich S, Lea-Chou E, Lopez-Uribe D, Shroyer K R
Abstract excerpt
Vulvar intraepithelial neoplasias (VINs) are potentially premalignant lesions of the squamous mucosa. The immunohistochemical distribution of the catalytic protein subunit of telomerase (hTERT) and the patterns of X chromosome inactivation were investigated as markers of neoplasia in samples from a patient with multifocal and diffuse VIN. hTERT nuclear staining in VIN correlated with squamous maturation and the...
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