Article
Plasmodium falciparum: molecular characterization of multidrug-resistant Cambodian isolates.
Experimental parasitology - 1 Mar 1996
Basco L K, de Pecoulas P E, Le Bras J, Wilson C M
Abstract excerpt
Clinical resistance to many therapies for malaria is a rapidly evolving problem in most endemic areas, particularly, Southeast Asia. Recent studies have suggested linkages between the mdr-like genes of Plasmodium falciparum and resistance to quinoline containing compounds. Other studies have found an association between allelic polymorphisms in the DHFR gene and antifol resistance in these parasites. The purpose...
Topics
- Alleles
- Animals
- Antimalarials
- Blotting, Southern
- Cambodia
- Chloroquine
- Codon
- DNA Fingerprinting
- DNA, Protozoan
- Drug Resistance, Multiple
- Folic Acid Antagonists
- Genes, Protozoan