Article
Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.
The EMBO journal - 1 Apr 1996
Léveillard T, Andera L, Bissonnette N, Schaeffer L, Bracco L, Egly J M, Wasylyk B
Abstract excerpt
The p53 tumour suppressor is mutated in the majority of human tumours. p53's proposed role as the guardian of the genome is reflected in its multiple effects on transcription genome stability, cell growth and survival. We show that p53 interacts both physically and functionally with the TFIIH complex. There are multiple protein-protein contacts, involving two regions of p53 and three subunits of TFIIH, ERCC2...
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