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Article

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.

Science (New York, N.Y.) - 23 Feb 1996

Paulusma C C, Bosma P J, Zaman G J, Bakker C T, Otter M, Scheffer G L, Scheper R J, Borst P, Oude Elferink R P

Abstract excerpt

The human Dubin-Johnson syndrome and its animal model, the TR(-) rat, are characterized by a chronic conjugated hyperbilirubinemia. TR(-) rats are defective in the canalicular multispecific organic anion transporter (cMOAT), which mediates hepatobiliary excretion of numerous organic anions. The complementary DNA for rat cmoat, a homolog of the human multidrug resistance gene (hMRP1), was isolated and shown to be...

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PMID: 8599091
DOI: 10.1126/science.271.5252.1126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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Click a neighbor to travelStep 1 · 12 closest

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.PMID 8599091Read ↗

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome.Semantic proximity Read ↗

[Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome].Semantic proximity Read ↗

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.Semantic proximity Read ↗

Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome.Semantic proximity Read ↗

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndromeSemantic proximity Read ↗

Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome.Semantic proximity Read ↗

MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte.Semantic proximity Read ↗

Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome.Semantic proximity Read ↗

Novel mutations in the Dubin-Johnson syndrome gene ABCC2/MRP2 and associated biochemical changes.Semantic proximity Read ↗

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Transfer of chloramphenicol-resistant mitochondrial DNA into the chimeric mouse.Semantic proximity Read ↗

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