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Article

Conformational behaviour of the antineoplastic peptide dolastatin-10 and of two mutated derivatives.

Journal of computer-aided molecular design - 1 Oct 1995

Fantucci P, Marino T, Russo N, Villa A M

Abstract excerpt

The three-dimensional structure of dolastatin-10, an extremely potent cytostatic and antineoplastic peptide extracted from the mollusc Dolabella auricularia, has not yet been fully characterized in an experimental way. By means of a systematic conformational search of the natural peptide and of two mutated analogs, carried out both in vacuo and in aqueous solution, the present work allows to obtain insights into...

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PMID: 8594160
DOI: 10.1007/BF00124000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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