Article
Intraphagocytic growth induces an antibiotic-resistant phenotype of Legionella pneumophila.
Antimicrobial agents and chemotherapy - 1 Dec 1995
Barker J, Scaife H, Brown M R
Abstract excerpt
The antimicrobial susceptibilities of Legionella pneumophila isolates grown either in U937 human monocytic cells or in Acanthamoeba polyphaga were studied after release from the host cells without further subculture. Time-survival studies showed that exposure of L. pneumophila cells, gown exclusively in vitro, to 5 micrograms of rifampin per ml resulted in at least 99% killing after 6 h and no detectable...
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