Use of Aminoglycosides in Treatment of Infections Due to Intracellular Bacteria

Abstract excerpt

Soon after antibiotics were introduced into medical practice, authors pointed out that microorganisms capable of surviving within phagocytic cells may be protected from the killing actions of antibiotics with a poor ability to cross the eukaryotic cell membrane, leading to therapy failures and disease relapses (86, 108). Following the pioneering work by Bonventre et al. (21) that showed that mouse peritoneal...

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