Article
Reduced recovery of a Cryptococcus neoformans adherence mutant from a rat model of cryptococcosis.
Canadian journal of microbiology - 1 Jan 2000
Merkel G J, Scofield B A, Rescorla F J, Yang R, Grosfeld J L
Abstract excerpt
Stable mutants of Cryptococcus neoformans (strain CSF-1) induced by treatment with ultraviolet light and nitrosoguanidine were isolated that demonstrated reduced adherence to glial cells in culture. Adherence of the mutants, as measured by a radiometric assay, was reduced by 50-70% of that attained for the parent CSF-1 strain. The adherence mutants appeared to be phenotypically similar to the CSF-1 strain....
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