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Article

Temperature sensitivity of the keratin cytoskeleton and delayed spreading of keratinocyte lines derived from EBS patients.

Journal of cell science - 1 Nov 1995

Morley S M, Dundas S R, James J L, Gupta T, Brown R A, Sexton C J, Navsaria H A, Leigh I M, Lane E B

Abstract excerpt

Point mutations in the keratin intermediate filament genes for keratin 5 or keratin 14 are known to cause hereditary skin blistering disorders such as epidermolysis bullosa simplex, in which epidermal keratinocytes are extremely fragile and the skin blisters on mild trauma. We show that in 2 phenotypically diverse cases of epidermolysis bullosa simplex, the keratin mutations result in a thermoinstability of the...

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Identifiers

PMID: 8586658
DOI: 10.1242/jcs.108.11.3463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Temperature sensitivity of the keratin cytoskeleton and delayed spreading of keratinocyte lines derived from EBS patients.PMID 8586658Read ↗

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Assays to Study Consequences of Cytoplasmic Intermediate Filament Mutations: The Case of Epidermal Keratins.Semantic proximity Read ↗

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A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases.Semantic proximity Read ↗

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