Article
Generation and characterization of epidermolysis bullosa simplex cell lines: scratch assays show faster migration with disruptive keratin mutations.
The British journal of dermatology - 1 Jul 2003
Morley S M, D'Alessandro M, Sexton C, Rugg E L, Navsaria H, Shemanko C S, Huber M, Hohl D, Heagerty A I, Leigh I M, Lane E B
Abstract excerpt
BACKGROUND: Epidermolysis bullosa simplex (EBS) is an inherited skin fragility disorder caused by mutations in keratin intermediate filament proteins. While discoveries of these mutations have increased understanding of the role of keratins and other intermediate filaments in epithelial tissues, progress towards the development of therapy for these disorders is much slower. OBJECTIVES: Cell culture model systems...
Topics
- Cell Division
- Cell Line
- Cell Movement
- Cell Transformation, Viral
- Child, Preschool
- DNA Mutational Analysis
- Epidermolysis Bullosa Simplex
- Hot Temperature
- Humans
- Intermediate Filaments
- Keratinocytes
- Keratins
- Mutation