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Article

Monoclonal lymphocyte proliferation and bcl‐2 rearrangement in essential mixed cryoglobulinaemia

1 Nov 1995

Abstract excerpt

A patient with essential mixed cryoglobulinaemia (EMC) type II and hepatitis C virus (HCV) infection, in whom immunophenotypic and genotypic studies demonstrated a clonal proliferation of B lymphocytes, is described. Fluorescent in situ hybridization with probes to Ig heavy chain gene and to the oncogene bcl-2 demonstrated a translocation of bcl-2 to the immunoglobulin heavy chain locus on chromosome 14. A sharp...

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PMID: 8582448
DOI: 10.1111/j.1365-2362.1995.tb01692.x

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