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Article

Neurofibromin-deficient fibroblasts fail to form perineurium in vitro.

Development (Cambridge, England) - 1 Nov 1995

Rosenbaum T, Boissy Y L, Kombrinck K, Brannan C I, Jenkins N A, Copeland N G, Ratner N

Abstract excerpt

To identify cell type(s) that might contribute to nerve sheath tumors (neurofibromas) in patients with neurofibromatosis type 1, we generated cell cultures containing neurons. Schwann cells and fibroblasts from transgenic mouse embryos in which the type 1 neurofibromatosis gene was disrupted by homologous recombination (Brannan et al. (1994) Genes Development, 8,1019-1029). Normal fascicle formation by...

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Identifiers

PMID: 8582272
DOI: 10.1242/dev.121.11.3583
PMCID: PMC2854496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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