Expression of a <i>Plasmodium</i> Gene Introduced into Subtelomeric Regions of <i>Plasmodium berghei</i> Chromosomes

Abstract excerpt

Targeted integration of exogenous DNA into the genome of malaria parasites will allow their phenotype to be modulated by means of gene disruption or the stable expression of foreign and mutated genes. Described here is the site-specific integration through reciprocal exchange, and subsequent expression, of a selectable marker gene into the genome of the pathogenic, bloodstage forms of the rodent malaria parasite...

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