Article
Characterization of lymphocyte beta-adrenoceptor activity and Gs-protein in patients with rheumatic heart valvular disease.
Fundamental & clinical pharmacology - 1 Jan 1995
Dzimiri N, Hussain S, Moorji A, Prabhakar G, Bakr S, Kumar M, Almotrefi A A, Halees Z
Abstract excerpt
In order to test whether the beta-adrenoceptor activity in rheumatic heart valvular disease depends on the ventricular load conditions, we determined their density and binding affinity to [125I]-iodocyanopindolol in lymphocytes, as well as plasma catecholamine and cAMP levels in 69 patients with regurgitant and stenotic lesions of the aortic and mitral valves. The patients were classified as having left...
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