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Article

Reversal of multidrug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol.

Cancer research - 1 Feb 1996

Christensen J G, LeBlanc G A

Abstract excerpt

A major obstacle to successful chemotherapy is the development of multidrug resistance (MDR) by cancer cells. MDR is characterized by enhanced cellular efflux of many structurally and functionally diverse compounds, including many anticancer drugs, due to overexpression of the MDR-1 gene product, P-glycoprotein. We hypothesized that the phytochemical, indole-3-carbinol (I3C), and some of its acid-condensation...

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PMID: 8564974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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