Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease

doi:10.1182/blood.v87.2.465.bloodjournal872465

Article

Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease

15 Jan 1996

Abstract excerpt

The BCL-6 gene encoding a nuclear-located Kruppel-type zinc finger protein is rearranged in about 30% diffuse large B-cell lymphomas and is expressed predominantly in normal germinal center B cells and related lymphomas. These findings suggest that BCL-6 may play a role in regulating differentiation of normal germinal center B cells and that its deregulated expression caused by rearrangements may contribute to...

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