[Application of molecular biology to occupational health field--the frequency of gene polymorphism of cytochrome P450 1A1 and glutathione S-transferase M1 in patients with lung, oral and urothelial cancer].

Abstract excerpt

A polymorphism in exon 7 of the cytochrome P450 1A1 (CYP1A1) and A homozygous gene deletion at the glutathione S-transferase M1 (GSTM1) locus of genomic DNA isolated from peripheral blood were investigated for its relationship with lung, oral and urothelial cancer using the polymerase chain reaction (PCR) technique. As for the CYP 1A1 Val/Val genotype, 5 of 88 healthy controls (5.6%), 1 of 33 lung cancer patients...

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