Article
Smoothness within ruggedness: the role of neutrality in adaptation.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 1996
Huynen M A, Stadler P F, Fontana W
Abstract excerpt
RNA secondary structure folding algorithms predict the existence of connected networks of RNA sequences with identical structure. On such networks, evolving populations split into subpopulations, which diffuse independently in sequence space. This demands a distinction between two mutation thresh...
Topics
- Adaptation, Biological
- Base Sequence
- Biological Evolution
- Genotype
- Mutation
- Nucleic Acid Conformation
- Phenotype
- RNA
- Selection, Genetic