Article
Mating-type suppression of the DNA-repair defect of the yeast rad6 delta mutation requires the activity of genes in the RAD52 epistasis group.
Current genetics - 1 Jun 1995
Yan Y X, Schiestl R H, Prakash L
Abstract excerpt
The RAD6 gene of Saccharomyces cerevisiae is required for post-replication repair of UV-damaged DNA, UV mutagenesis, and sporulation. Here, we show that the radiation sensitivity of a MATa rad6 delta strain can be suppressed by the MAT alpha 2 gene carried on a multicopy plasmid. The a1-alpha 2 s...
Topics
- DNA Damage
- DNA Repair
- DNA Replication
- DNA-Binding Proteins
- Epistasis, Genetic
- Fungal Proteins
- Ligases
- Mutation
- Plasmids
- Rad52 DNA Repair and Recombination Protein
- Radiation Tolerance
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Ubiquitin-Conjugating Enzymes
- Ultraviolet Rays