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Article

Clonal Determination of Uterine Leiomyomas by Analyzing Differential Inactivation of the X-Chromosome-Linked Phosphoglycerokinase Gene

1 Mar 2010

Abstract excerpt

To investigate the clonality of uterine leiomyomas, we developed a PCR-based method involving the differential inactivation of the X-chromosome-linked phosphoglycerokinase (PGK) gene. Small DNA samples of 22 leiomyomas from 9 Japanese patients, showing heterozygosity at the BstXI site of the PGK gene, were digested with the methylation-sensitive restriction enzyme HpaII. Only the inactive (methylated) PGK gene...

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Identifiers

PMID: 8529956
DOI: 10.1159/000292336

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Source receipt: pubmed, retrieved 7 Sept 2026.

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