Article
Apolipoprotein E epsilon 4 in inclusion body myositis.
Annals of neurology - 1 Dec 1995
Garlepp M J, Tabarias H, van Bockxmeer F M, Zilko P J, Laing B, Mastaglia F L
Abstract excerpt
The genetic predisposition to inclusion body myositis (IBM) is probably multifactorial. The deposition of the beta-amyloid protein is a characteristic histological feature of both IBM and Alzheimer's disease (AD). The epsilon 4 allele of apolipoprotein E (APO E) has been strongly associated with familial and late-onset AD. We therefore compared the APO E allele frequencies in a group of 14 patients with IBM with...
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