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Article

Complete inhibition of virion assembly in vivo with mutant procapsid RNA essential for phage phi 29 DNA packaging.

Journal of virology - 1 Jan 1996

Trottier M, Zhang C, Guo P

Abstract excerpt

A highly efficient method for the inhibition of bacteriophage phi 29 assembly was developed with the use of mutant forms of the viral procapsid (or packaging) RNA (pRNA) indispensable for phi 29 DNA packaging. Phage phi 29 assembly was severely reduced in vitro in the presence of mutant pRNA and completely blocked in vivo when the host cell expressed mutant pRNA. Addition of 45% mutant pRNA resulted in a...

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Identifiers

PMID: 8523569
DOI: 10.1128/JVI.70.1.55-61.1996
PMCID: PMC189787

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