Complete inhibition of virion assembly in vivo with mutant procapsid RNA essential for phage phi 29 DNA packaging.

doi:10.1128/JVI.70.1.55-61.1996

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Article

Complete inhibition of virion assembly in vivo with mutant procapsid RNA essential for phage phi 29 DNA packaging.

Journal of virology - 1 Jan 1996

Trottier M, Zhang C, Guo P

Abstract excerpt

A highly efficient method for the inhibition of bacteriophage phi 29 assembly was developed with the use of mutant forms of the viral procapsid (or packaging) RNA (pRNA) indispensable for phi 29 DNA packaging. Phage phi 29 assembly was severely reduced in vitro in the presence of mutant pRNA and...

Topics

Bacillus Phages
Base Sequence
Binding Sites
Capsid
DNA, Viral
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
RNA, Viral
Virion
Virus Assembly

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