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Article

Substrate recognition at the binding site in mammalian pancreatic alpha-amylases.

Biochemistry - 22 Jun 1993

Ishikawa K, Matsui I, Kobayashi S, Nakatani H, Honda K

Abstract excerpt

Porcine and human pancreatic alpha-amylases (PPA and HPA, respectively) have five binding sites for hexose residues of substrates. As previously reported, when a substrate is too small to occupy subsite 5 of the alpha-amylases, the optimum pH for catalytic activity changes from neutral to acidic [Ishikawa, K., Matsui, I., Honda, K., & Nakatani, H. (1990) Biochemistry 29, 7119-7123]. We studied the mechanism by...

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PMID: 8512936
DOI: 10.1021/bi00075a020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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