Iron distribution in Belgrade rat reticulocytes after inhibition of heme synthesis with succinylacetone.

Article

Iron distribution in Belgrade rat reticulocytes after inhibition of heme synthesis with succinylacetone.

Blood - 15 Jun 1993

Garrick L M, Gniecko K, Liu Y, Cohan D S, Grasso J A, Garrick M D

Abstract excerpt

We have used succinylacetone (4,6-dioxoheptanoic acid), a specific inhibitor of delta-aminolevulinic acid dehydrase, to gain insight into the defect in iron metabolism in the Belgrade anemia. The Belgrade rat has an inherited microcytic, hypochromic anemia associated with poor iron uptake into developing erythroid cells. Succinylacetone inhibits heme synthesis, leading to nonheme iron accumulation in mitochondria...

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