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Article

Multiple effects of lcrD mutations in Yersinia pestis.

Journal of bacteriology - 1 Jun 1993

Plano G V, Straley S C

Abstract excerpt

Plasmid pCD1 of Yersinia pestis contains a low-calcium response stimulon responsible for the temperature- and calcium-regulated expression and secretion of proteins involved in virulence, which include the V antigen and Yops. We have previously shown that insertional inactivation of the bicistronic lcrDR operon abolished the calcium requirement for growth at 37 degrees C and reduced expression of the V antigen...

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Identifiers

PMID: 8501057
DOI: 10.1128/jb.175.11.3536-3545.1993
PMCID: PMC204754

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Research trail→

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Multiple effects of lcrD mutations in Yersinia pestis.PMID 8501057Read ↗

lcrR, a low-Ca2(+)-response locus with dual Ca2(+)-dependent functions in Yersinia pestis.Semantic proximity Read ↗

YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops.Semantic proximity Read ↗

Mutations in yscC, yscD, and yscG prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis.Semantic proximity Read ↗

A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH.Semantic proximity Read ↗

Regulation by Ca2+ in the Yersinia low-Ca2+ response.Semantic proximity Read ↗

YscP of Yersinia pestis is a secreted component of the Yop secretion system.Semantic proximity Read ↗

The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG.Semantic proximity Read ↗

LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis.Semantic proximity Read ↗

The type III secretion chaperone LcrH co-operates with YopD to establish a negative, regulatory loop for control of Yop synthesis in Yersinia pseudotuberculosis.Semantic proximity Read ↗

YscB of Yersinia pestis functions as a specific chaperone for YopN.Semantic proximity Read ↗

Regulated secretion of YopN by the type III machinery of Yersinia enterocolitica.Semantic proximity Read ↗

YopM inhibits platelet aggregation and is necessary for virulence of Yersinia pestis in mice.Semantic proximity Read ↗

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