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Article

Molecular genetic analyses in neurofibromatosis type 1 patients with tumors.

Cancer genetics and cytogenetics - 1 Mar 2006

Oguzkan Sibel, Terzi Yunus Kasim, Cinbis Mine, Anlar Banu, Aysun Sabiha, Ayter Sukriye

Abstract excerpt

Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant disorders. NF1 is clinically characterized by neurofibromas, pigmentation anomalies, and an increased risk of malignant tumors. The NF1 gene product, neurofibromin, has a GTPase-activating protein domain (GRD) that interacts with the Ras protein, which is crucial in regulating signal transduction and cell proliferation/differentiation. We...

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Identifiers

PMID: 16527612
DOI: 10.1016/j.cancergencyto.2005.08.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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