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Article

Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection.

Journal of virology - 1 Jun 1993

Zhang L Q, MacKenzie P, Cleland A, Holmes E C, Brown A J, Simmonds P

Abstract excerpt

Viral RNA was extracted from plasma samples collected from five individuals during the period of viremia before seroconversion in primary infection with human immunodeficiency virus type 1 (HIV-1) and amplified by polymerase chain reaction. Nucleotide sequence analysis of amplified DNA from the V3 and V4 hypervariable regions indicated that the initial virus population of each acutely infected individual was...

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Identifiers

PMID: 8497055
DOI: 10.1128/JVI.67.6.3345-3356.1993
PMCID: PMC237678

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