Article
Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni.
Carcinogenesis - 1 Apr 1993
Badawi A F, Cooper D P, Mostafa M H, Doenhoff M J, Probert A, Fallon P, Cooper R, O'Connor P J
Abstract excerpt
Male and female BK-TO mice were infected with different numbers of Schistosoma mansoni cercariae under standard environmental conditions. Promutagenic methylation damage (O6-methyldeoxyguanosine; O6-MedG) was detected in liver DNA, but not in kidney, spleen or bladder DNA of infected animals. It was shown that levels of hepatic O6-MedG increased with increasing intensities of schistosomal infection. Possible...
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