Article
The structure and characteristics of a fourth allele of polymorphic N-acetyltransferase gene found in the Japanese population.
Biochemical and biophysical research communications - 31 Mar 1993
Abe M, Deguchi T, Suzuki T
Abstract excerpt
Polymorphic N-acetyltransferase (NAT2), which exists in the human liver and metabolizes a wide spectrum of arylamine, is encoded by one gene (NAT2). We have identified the mutations of a fourth NAT2 allele (allele 4) which we previously found in the Japanese population. Compared with allele 1, which expresses a high enzyme activity, allele 4 has 3 nucleotide differences. 2 are missense mutations at nucleotide...
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