Detection of beta-thalassemia carrier by direct analysis of beta-globin gene lesions.

doi:10.1006/bbrc.1993.1332

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Article

Detection of beta-thalassemia carrier by direct analysis of beta-globin gene lesions.

Biochemical and biophysical research communications - 31 Mar 1993

Pao C C, Lin C Y, Tang G C, Sun C F, Hsieh T T

Abstract excerpt

DNA was prepared from peripheral blood mononuclear cells of 114 Chinese with low erythrocyte mean corpuscular volume and analyzed by allele-specific DNA amplification for the presence of mutant alleles in the beta-globin gene that account for about 90% of beta-thalassemia in Chinese. A total of 9...

Topics

Alleles
Base Sequence
Genes
Globins
Heterozygote
Humans
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Polymerase Chain Reaction
beta-Thalassemia

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